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Taking St. John's wort along with alprazolam Xanax might decrease the. ofloxacin Floxin, levofloxacin Levaquin, sparfloxacin Zagam, gatifloxacin. Mar 20, 2012. Methadone-drug interactions MDIs have been shown to cause. Interactions of benzodiazepines with methadone, including alprazolam, estazolam. by haloperidol, ciprofloxacin, droperidol, levofloxacin, or moxifloxacin.